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On the Individual Specificity of Human Serum^*

From the New York Hospital and the Department of Pediatrics, Cornell University Medical College

Abstract

Recent studies of Cumley and Irwin (1, 2, 3) have suggested that serum proteins may be innately different in individuals of the same species (birds or man). In general, previous attempts to demonstrate this have not been successful (4). As far as we could ascertain, no confirmation of the results of Cumley and Irwin have been published. The existence of these differences would be of interest in the study of diseases where genetic factors are important, such as Rheumatic Fever (5). Therefore, an attempt was made to repeat the experiments of Cumley and Irwin.

In general, the technic of Cumley and Irwin was used. Immune sera were obtained by the injection of rabbits with sera from 2 rheumatic children and absorbed with sera of 4 non-rheumatic adults. One of the rheumatic children had acute rheumatic fever and his blood contained C-reactive protein; the other child was convalescing from acute rheumatic fever and had no C-reactive protein in his blood.

Footnotes

^* This study was aided by a grant from the Commonwealth Fund.