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The Journal of Immunology, 1948, 60: 503-515.
Copyright © 1948 by The American Association of Immunologists, Inc.
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A Comparison of Antigenicity and Certain Biological Characteristics of 6 Substrains of Pasteur Fixed Rabies Virus

John T. Wright1 and Karl Habel2,3,

Abstract

1. Substrains of Pasteur fixed rabies virus are not identical in their antigenicity, incubation period, duration of symptoms, pathology, or in their ability to overcome rabies immunity in immunized mice.
2. Ability to overcome immunity would seem to be a sensitive characteristic capable of differentiating viruses of rabies of the same ancestry but of differing biological evolution and may be shown by methods of testing other than the intracerebral cross immunity test.

Footnotes

1 Biologics Control Laboratory, National Institute of Health.

2 Division of Infectious Diseases, National Institute of Health.

3 Surgeons, U. S. P. H. S.






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