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Studies in Cellular Growth

III. Effect of Antigranulation-Tissue-Serum on Wound Healing in Mice^1,2,

From The Tobey Maltz Foundation³

Abstract

The accelerative effect of antisplenic-tissue-serum (ASTS) on the healing rate of experimental wounds in mice and guinea pigs (1, 2) suggested that an antiserum prepared against some cellular elements more directly active in the healing of wounds might be more effective than the ASTS. This paper reports some effects of antisera prepared against granulation tissue (antigranulation-tissue-serum, AGTS) on wound healing in mice. Two types of antisera were used: one against murine granulation tissue and a "heterologous" antiserum against human granulation tissue.

Methods and Materials. Antigens: Elliptical sections of skin were scissored from the backs of 100 mice (CFW strain, Carworth Farms). Four days later scabs were removed and the curetted granulations were dispersed in saline solution (1 gm in 5 ml) in a Waring blendor. The suspension was lightly centrifuged and the supernate stored at -20 C. Human granulation tissue came from an open wound on the arm created by the formation of a tubed-pedicle graft.

Footnotes

¹ Nathan Block, MD, 57 West 57 Street, New York, N. Y.

² Antisera prepared by Biological Laboratories, 16 Clinton St., Brooklyn 2, N. Y.

³ From The Tobey Maltz Foundation, 57 West 57 St., New York, N. Y.