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Quantitative Studies of Complement-Fixation

III. Homologous and Cross-Reactions in Pneumococcal Type III and VIII Systems^*

From the Departments of Bacteriology and Medicine, Columbia University College of Physicians and Surgeons, and the Presbyterian Hospital, in the City of New York

Abstract

1. Data are given on precipitation and fixation of C' by S III and S VIII in reactions with homologous and cross-reacting antibodies.

2. Fixation in the homologous systems closely parallels the course of the preicipitn-reactions at higher concentrations.

3. As in the precipitin-reaction, S III is a more efficient reactant with anti-S VIII than S VIII is with anti-S III.

4. While the course of cross-fixation between S VIII and anti-S III differs from the homologous reaction much as does the corresponding precipitin-reaction, the reciprocal cross-reaction parallels the S VIII anti-S VIII reaction.

Footnotes

^* The work reported in this communication was carried out in part under a grant from the Rockefeller Foundation and in part under the Harkness Research Fund of the Presbyterian Hospital.