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The Mouse-Protective Test As a Means of Determining the Inhibitory Effect of Chemicals on Vibrio Cholera

Lederle Laboratories Division, American Cyanamid Company, Pearl River, New York

Abstract

Mouse-protective tests were carried out against Vibrio cholera using fifty-seven different chemicals. The chemicals were selected because of activity in in vitro tests against Vibrio cholera as reported by McKenzie and co-workers. The only chemicals showing superior activity were 2-sulfanilamidopyrimidine and its 5-bromo, 5-chloro, and 4-methyl derivatives. Animals having been protected by chemicals were immune when re-inoculated with Vibrio cholera. The xanthene dye, pyronin Y, and the thiazine dye, new methylene blue N, showed slight activity.