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The Journal of Immunology, 1948, 60: 295-298.
Copyright © 1948 by The American Association of Immunologists, Inc.
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Comparison of Mouse-Protective Tests and Chick-Protective Tests of Over 600 Chemicals Against Pasteurella Multocida

Paul Little, G. DeMello, J. Tanzola and Y. Subbarow

Lederle Laboratories Division, American Cyanamid Company, Pearl River, New York

Abstract

Mouse-protective tests and chick-protective tests have been used to determine possible in vivo activity for over 600 chemicals tested for in vitro activity against P. multocida by McKenzie and co-workers (1948). None of the chemicals other than the sulfonamides showed in vivo activity against Pasteurella multocida. The chemicals showing superior activity were 2-sulfanilamidopyrimidine, 2-sulfanilamidopyrazine and their chloro-, bromo-, and methyl derivatives.






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