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The Effect of Certain Enzyme Inhibitors on the Activity and Growth of Psittacosis Virus

Camp Detrick, Frederick, Md.

Abstract

1. The antiviral activity of various enzyme inhibitors was tested on psittacosis virus in vitro. Iodoacetamide, p-chloromercuribenzoate, hydroquinone, proflavine, atabrine, and mercuric chloride markedly reduced the activity of psittacosis virus as measured by egg titrations.

2. Glutathione and cysteine were shown to antagonize the effect of p-chloromercuribenzoate on psittacosis virus, resulting in resumption of virus activity.

3. Growth of psittacosis virus in tissue culture was inhibited after exposure of the tissue medium to o-iodosobenzoate or hydroquinone.

4. The significance of these findings in relation to the enzymic make-up and requirements of psittacosis virus is discussed.

Footnotes

^* Present Address: Bio-Science Laboratories, Inc., 10717 Venice Blvd., Los Angeles 34, Calif.