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Quantitative Studies of Complement Fixation

II. Fixation of Complement in the Reaction Between Type III Pneumococcus Specific Polysaccharide and Homologous Antibody^*

Departments of Bacteriology and Medicine, College of Physicians and Surgeons, Columbia University, and the Presbyterian Hospital in the City of New York

Abstract

1. Data are given which chart the course of the C' fixation reaction at 37 C. in experiments with constant amounts of S III and increasing quantities of anti-S III as well as with varying amounts of S III and constant antibody.

2. Analogies and differences between the C' fixation and precipitin reactions are demonstrated and discussed.

3. A calibrated curve of C' fixation at constant antibody and varying S III may be used for the estimation of unknown quantities of S III of the order of fractions of a microgram. A calibrated curve of C' fixation at constant S III and varying antibody may be used for the estimation of microgram quantities of antibody N.

Footnotes

^* The work reported in this communication was carried out in part under a grant from the Rockefeller Foundation and in part under the Harkness Research Fund of the Presbyterian Hospital.