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The Complement Fixation Test in Yellow Fever Epidemiology^*

II. The Development and Loss of Complement-Fixing Antibodies in Marmosets (Callithrix Penicillata, C. Jacchus and Leontocebus Chrysomelas)

From the Laboratory of the Yellow Fever Research Service, Rio de Janeiro, Brazil

Abstract

Marmosets surviving yellow fever infection develop complement-fixing antibodies, which reach a maximum titer in about four to five weeks after infection. These antibodies gradually disappear. Only in one of 26 animals did they persist as long as 360 days.

This finding may be applied in epidemiological studies to identify recently infected wild marmosets captured in areas under investigation.

Footnotes

^* The studies and observations on which this paper is based were conducted with the support and under the auspices of the Servico de Estudos e Pesquisas sôbre a Febre Amarela (Yellow Fever Research Service) of the Ministry of Education and Health of Brazil in cooperation with the International Health Division of The Rockfeller Foundation.