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The Specific Antigenic Properties of the Four Groups of Human Erythrocytes¹

From the Evans Memorial, Boston

Abstract

Normal rabbit sera possess weak agglutinins for the four groups of human erythrocytes. In certain rabbits this agglutinative capacity is group-specific, being particularly marked for groups II and IV cells.

Each of the four types of human sera contains agglutinins for rabbit erythrocytes. No group-specificity is manifested. Human isohemagglutinin "b," present in group I and II sera, is specifically adsorbed by rabbit cells.

Group-specific hemagglutinins, demonstrable by appropriate adsorption, were produced by injection of rabbits with type cells. The specific isoagglutinative activity of any type of human serum can thus be duplicated.

Group I cells, at least those of certain individuals, were found to contain a specific agglutininogenic component that does not exist in the other group cells examined.

Group-specific hemolysins or alexin-binding antibodies are developed with the agglutinins.

Many rabbits fail to produce group-specific antibodies; no cause for this individual variation was discovered. The fundamental importance of the animal's individuality in its bearing on serologic studies is emphasized.

Footnotes

¹ Presented at the Eighth Annual Meeting of the American Association of Immunologists, Cleveland, Ohio, March 25, 1921.