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Immunological Experiments with Catalase¹

From the Department of Physiology and the Department of Biochemistry and Pharmacology of the University of California, Berkeley

Abstract

The sera from rabbits which had received repeated injections of catalase prepared from calf liver, when mixed with the homologous antigen, gave a precipitate which carried with it catalase from the solution, in amounts dependent on the quantities of sera used. There was no evidence that a true inhibitory antibody was present in the sera of the injected animals, since the precipitate was as active as the antigen in the liberation of oxygen from neutral H₂O₂. The theoretical aspects of the results are discussed.

Footnotes

¹ Aided by a grant from the Research Fund of the University of California.