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Polyvalent Antibody Response to Multiple Antigens

From the Mulford Biological Laboratories

Abstract

The simultaneous production in a single individual of antibodies against each of a number of strains of bacteria or bacterial antigens is not only of theoretical interest but of practical value as well.

The employment of prophylactic immunization against disease and the use of immune sera to combat specific infection would be greatly facilitated if an adequate antibody production combined with a wide polyvalency could be assured.

The possible objections to such immunizations are entirely based on the theory that the simultaneous treatment with a number of antigens does not produce as great an antibody response to each antigen as can be obtained with single strains or antigens.

It is undoubtedly true in many instances that attempts at multiple immunizations fail to produce adequate antibody response. But it is not true in all instances, and this leads us to examine the factors which limit such polyvalent antibody production.