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A Note on the Claim That Agglutinins Are Lipoidal in Nature

From the Bureau of Laboratories, Department of Health, City of New York

Abstract

The claim that agglutinins could be extracted from sera by the use of lipoidal solvents, was called to our attention by the address of Jobling (1) on the relation of lipoids to immunity. This claim was made by Stuber (2), (3) who believed he had demonstrated that he could extract the agglutinins from an immune serum with petroleum ether and that the addition of the extracted substances to normal serum would result in an agglutinating value practically equal to that of the unextracted immune serum. He claimed, also, that the serum of normal animals became strongly agglutinative after the animals had received intravenous injections of such extracted substances.

We have attempted to duplicate the results of Stuber without success. However, we hesitated about presenting our findings, first, because of their negative character and secondly, because of a later article by Stuber (3) on the same subject.