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The Journal of Immunology, 1921, 6: 103-115.
Copyright © 1921 by The American Association of Immunologists, Inc.
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VII. Report on the Prophylactic Vaccination of 1536 Persons Against Acute Respiratory Diseases, 1919–1920

Anna I. von Sholly and William H. Park

Abstract

The reason for the investigation upon which this report is based, was to attempt to help clear up, if possible, the status of a vaccine made of the mixed organisms which predominate in respiratory diseases, used as a prophylactic agent in epidemic "grippe" and acute respiratory diseases in general. Reports on vaccine prophylaxis are only too plentiful both for a vaccine made of pure Bacillus influenzae and for a vaccine made of various mixtures of the important microbes found in the respiratory tract. The chief criticisms to the recognition of their claims is that they were tested out during the late pandemic of "grippe" either close to or after the peak of the epidemic, at a time when it was impossible to sort out cases into convincing statistical groups on account of the unknown factor of natural or inherited immunity which plays an important and as yet, little charted part in epidemiology.




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