HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Weinstein, L. Search for Related Content PubMed Articles by Weinstein, L.

The Action of Urea and Some of Its Derivatives on Bacteria^*

VIII. The Antibacterial Activity of Hexyl Carbamate, Alone and in Combination with Sulfonamides, and Its Effect on Para-Aminobenzoic Acid

Haynes and Evans Memorials, Massachusetts Memorial Hospitals, and the Department of Medicine, Boston University School of Medicine, Boston, Mass.

Abstract

The experiments reported in this paper indicated that hexyl carbamate was able to produce inhibition of growth of several gram-negative and gram-positive bacteria. The concentration of this compound required to suppress bacterial multiplication was found to be less than that necessary with urea, urethane, propyl or isopropyl carbamate, and butyl or isobutyl carbamate. These results emphasize the previously recorded observation that an increase in the number of carbon atoms in the alkyl chain replacing one of the—NH₂ groups in urea results in augmentation of antibacterial activity. A concentration of the hexyl compound sufficient to kill bacteria could not be obtained; this was probably due to its relative insolubility.

Footnotes

^* This study was aided by a grant from the Johnson Research Foundation, New Brunswick, New Jersey.