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In Vitro Action of Various Chemical Agents on Trichomonas Hominis, Trichomonas Vaginalis and Trichomonas Foetus^1,2,

From the Department of Pharmacology and Toxicology, University of Wisconsin Medical School, Madison

Abstract

Trichomonads are actively motile, flagellated, pear-shaped protozoa which occur widely as parasites in man and other animals. Infections may vary in degree of severity depending on the individual host reaction, but they are generally difficult to eradicate. Many types of treatment are recommended, but no reliably efficient chemotherapeutic agents are available; therapeutic procedures are largely empirical and therapy is apt to be uncertain and unsatisfactory.

Attempts to infect animals with bacteria-free cultures of Trichomonas vaginalis (1) have met with little success. In this laboratory, rabbits could not be infected by Trichomonas hominis inoculated intravaginally, and experimental infections of Trichomonas foetus in the vagina of the rabbit are too irregular and unpredictable for practical in vivo tests (2–4). Therefore, in vitro tests on clinical material or on cultures of the organisms remain as a basis for evaluating drugs, particularly for substances which may be expected to act promptly.

Footnotes

¹ Supported in part by the Research Committee of the Graduate School from funds supplied by the Wisconsin Alumni Research Foundation and in part by The Upjohn Company, Kalamazoo, Michigan.

² A preliminary report of this work was read at the Chicago meeting of the American Society for Pharmacology and Experimental Therapeutics in May 1947, and published in Federation Proceedings 6:353 (Mar.) 1947.

³ Submitted to the Graduate School of the University of Wisconsin in partial fulfillment of the requirements for the degree of Doctor of Philosophy.