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Anaphylaxis XVIII: Studies on Passive Sensitization of the Dog¹

From the Departments of Bacteriology and Physiology of the University of Kansas, Lawrence, Kansas

Abstract

The concept that a latent period for passive sensitization of the dog is essential has been widely accepted for many years. Lewis (1) states, "The earliest experiments in the transference of hypersusceptibility from one animal to another clearly showed that a definite interval of time must elapse between the injections of sensitizing antiserum and antigen." He further states that the interval is usually 24 hours but may be reduced to 4 hours under optimum condition; that it is, "Generally agreed that the latent period cannot be entirely dispensed with." Zinsser, Enders, and Fothergill (2) are of the same opinion since they state that in passive sensitization a definite period must elapse between the injection of sensitive blood and that of antigen. Apparently Dragstedt (3, 4) does not challenge these conclusions since he states that a latent period "... has been shown to be necessary for the guinea pig and the dog."

Footnotes

¹ This work was supported by a grant from the Graduate Research Committee of the University of Kansas