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The Inactivation of Influenza Virus by Mercurials and the Reactivation by Sodium Thioglycolate and Bal¹

From the Department of Bacteriology, School of Medicine, University of Pennsylvania, Philadelphia 4, Pa., and the Bacteriological Research Laboratories of Hynson, Westcott and Dunning, Baltimore, Md.

Abstract

Six mercurials were tested for their in vitro activity against influenza virus. HgCl₂, merbromin, merodicein, metaphen and phenyl mercuric nitrate effectively inactivated influenza virus. Merthiolate possessed little in vitro activity against influenza B virus. Merodicein instilled intranasally possessed some prophylactic activity against influenza virus.

The inactivation of influenza virus by HgCl₂ could be reversed in vitro with either sodium thioglycolate or BAL. The intramuscular injection of BAL also effected the in vivo reactivation of the virus.

Footnotes

¹ This investigation has been aided by grants from the Josiah Macy, Jr. Foundation and from the Theresa F. Felsen Memorial Fund.