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Studies on the Interference Phenomenon with Certain Members of the Psittacosis-Lymphogranuloma Group of Viruses

Camp Detrick, Frederick, Md.

Abstract

Previous infection of embryonated egg tissues with the virus of meningopneumonitis was shown to interfere with the growth of psittacosis virus subsequently inoculated. The quantitative and time relationships were seen to be of prime importance in the successful demonstration of this phenomenon.

Meningopneumonitis virus partially inactivated by heat or inactivated by ultra-violet light irradiation retained properties of interference, reducing the yield of psittacosis virus in eggs as much as 99 per cent in the case of the heated preparations.

Mice inoculated intraabdominally with meningopneumonitis virus were shown to develop an increased resistance to subsequent inoculations of psittacosis virus within a very few days.

Under the conditions of the experiments, mouse pneumonitis virus did not show an interference effect against psittacosis virus in embryonated eggs or mice.