HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Halbert, S. P. Articles by Magnuson, H. J. Search for Related Content PubMed Articles by Halbert, S. P. Articles by Magnuson, H. J.

Studies with Antibiotic-Producing Strains of Escherichia Coli^*

From the Reynolds Research Laboratory, School of Public Health, University of North Carolina, Chapel Hill, North Carolina

Abstract

1. It has been shown that eleven strains of E. coli, which are antagonistic in the living state against a Shigella parcdysenterice Flexner type III, are capable of producing antibiotic when grown on the surface of agar media. Little or no antibiotic developed under various conditions of broth culture.

2. Four strains of E. coli, non-antagonistic in the living state were not capable of producing antibiotic under similar conditions.

3. It has been possible to obtain moderate yields of antibiotic with several strains on a simple synthetic medium.

4. The presence of as much as 25 per cent human serum does not interfere with the action of the antibiotics tested.

5. The properties of the antibiotic of one strain, E. coli 534, have been studied in some detail. They are very similar to those of the substance described by Heatley and Florey (1).

Footnotes

^* This work was aided in part by funds granted by the U. S. Public Health Service to the University of North Carolina.