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Serological Studies on Infectious Mononucleosis and Other Conditions with Human Erythrocytes Modified by Newcastle Disease Virus¹

From the Section of Preventive Medicine, Yale University School of Medicine, New Haven, Connecticut

Abstract

1. Serological reactions with human red blood cells modified by adsorption and elution of Newcastle disease virus (NDV) have been studied.

2. Serum from some patients with infectious mononucleosis agglutinated such NDV-treated red cells in higher titer than serum from normal persons or from patients with non-infectious diseases.

3. Similarly high titers were observed in the serum of some patients with other infectious diseases.

4. Serum from rabbits immunized against Newcastle disease virus or against three other immunologically unrelated viruses agglutinated NDV-treated red cells in higher titer than normal rabbit serum or serum from a rabbit immunized against normal chick embryo tissue.

5. Human serum as well as serum from rabbits immunized with viruses other than Newcastle disease virus, which agglutinated NDV-treated human red cells in high titer, failed to inhibit the agglutination of chicken red cells by Newcastle disease virus except for the serum of one patient which, however, failed to neutralize the virus.

6. The capacity of both human and immune rabbit sera to agglutinate NDV-treated human red cells appeared to be unrelated either to the heterophile antibody of infectious mononucleosis or to the hypothetical agent of that disease.

Footnotes

¹ Representing work done for the Virus and Rickettsial Commission, Army Epidemiological Board, Office of The Surgeon General, U. S. Army, Washington, D. C.