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Attempt to Produce Protection against Mosquitoes by Active Immunization¹

From the Division of Pathology and Bacteriology, University of Tennessee College of Medicine, Memphis and from the Department of Health and Safety, Tennessee Valley Authority

Abstract

In this experiment the attempt to protect rabbits against mosquitoes by vaccination with mosquito antigen proved unsuccessful. Moreover, the rabbits so inoculated with a crude suspension of mosquitoes became sensitized to mosquito bites in contrast to the normal non-sensitive rabbits. The sensitized rabbits showed large indurated reddened papules at the site of the bites. These cutaneous reactions began in about 30 minutes and reached their maximum size at about 5 hours.

Attempts at desensitization of the sensitive animals were unsuccessful under conditions of the present experiment. Passive transfer of the sensitivity to normal animals was also tried but without success.

Footnotes

¹ This work was supported in part by a grant-in-aid from the Tennessee Valley Authority.

² Present address—University of Mississippi, Oxford, Mississippi.