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Immunochemistry of Toxins and Toxoids

IV. The Preparation of Purified Diphtherial Toxoid for Clinical Use¹

From the Institute of Pathology, Western Reserve University, Cleveland, Ohio

Abstract

Special methods are described for the preparation of a stable, purified diphtherial toxoid which is suitable for human immunization. The addition of glycine to the toxoid permits freezing, drying, and sterile filtration with no impairment in the antigenicity of the toxoid principle.

The purified toxoids may be alum precipitated and are highly stable in this form or in the fluid state. The antigenic response in guinea-pigs and in human beings is high and durable.

Footnotes

¹ Aided by a grant from Lederle Laboratories Division, American Cyanamid Company.

² Lederle Laboratories, Pearl River, N. Y.