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Observations on Antibiotic Coaction of Gramicidin and Penicillin on Streptococci and Staphylococci in Vitro

From Wallace Laboratories, Inc., Princeton, New Jersey

Abstract

Gramicidin in minimal effective concentrations has a more rapid bactericidal action on susceptible bacteria than does penicillin in amounts approaching minimum effective concentrations.

Mixtures of gramicidin and penicillin have a more efficient bactericidal and bacteriostatic action than either drug when used alone in comparable quantities.