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Changes in Embryonated Eggs Inoculated with Influenza Virus

From the Section Virus del Instituto Bacteriológico "Malbrán", Secretaría de Salud Pública de la Nación, Buenos Aires, Republica Argentina¹

Abstract

In experimental work with viruses special attention has been given to their immunological and physicochemical properties. Relatively little study has been made of the interaction between the virus and the host, and this has been limited to pathological changes in the infected tissue. The metabolic changes in the host produced by the presence and reproduction of a virus have not been systematically investigated, and we believe that a knowledge of these changes may be helpful to a better understanding of the virus-host interactions.

Burnet (1, 2) studied the pathological changes produced in the chorioallantoic membrane and embryo of the chick by influenza A virus. We were impressed, however, by the fact that the pH values of the allantoic fluid of chick embryos infected with influenza A virus were always higher than normal. This was so striking that in our routine work we used it as a primary test of infection and discarded all fluids that gave a yellow or light green color with brom-thymol blue.

Footnotes

¹ These studies were supported in part by a grant from the International Health Division of The Rockefeller Foundation.