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Responses of Human Subjects to Vaccines in Saline-in-Mineral Oil Emulsion

I. Shigella Paradysenteriae Vaccines^*

Department of Bacteriology, School of Medicine, University of Pennsylvania, Philadelphia 4, Pa.

Abstract

A total of 3.0 billion Shigella paradysenteriae bacterial cells in saline or totals of 0.6 and 1.2 billion cells emulsified in mineral oil were administered to groups of human subjects. The subjects experienced slight but similar systemic reactions; increases in mouse protective antibody titers were of low order and similar in the saline and oil vaccine groups. One abscess attributable and one possibly attributable to the oil vaccine developed out of a total of 140 oil injection sites. Under the conditions in which they were tested in humans, the oil emulsion vaccines did not show a marked improvement of the antigenicity to toxicity ratios.

Footnotes

^* The work described in this paper was done in part under a contract, recommended by the Committee on Medical Research, between the Office of Scientific Research and Development and the University of Pennsylvania, and was aided by the Theresa F. Felsen Memorial Fund.