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Neurologic Manifestations in Laboratory Animals Produced by Organ (Adjuvant) Emulsions

From the Department of Bacteriology, New York State Psychiatric Institute, New York, N. Y.

Abstract

Although these experimental results are limited by the small number of animals used it would appear that:

1. Neurologic disturbances, characterized chiefly by paralysis of the hind limbs, have been induced in normal guinea pigs by single subcutaneous injections of emulsions of homologous and heterologous brain and heterologous kidney, containing Freund's adjuvants, as well as similar preparations of alcoholic extracts of brain. Testicle emulsions were without effect in normal guinea pigs, but induced hind leg paralysis in 2 guinea pigs which had previously received injections of various organ suspensions.

2. It was also possible to produce this phenomenon in rabbits by repeated injections of adjuvant-emulsions of both rat brain and alcoholic extract of sheep brain in combination with egg-white.