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Persistence of Antigen at the Site of Inoculation of Vaccine Emulsified in Oil^*

Abstract

1. A technic was developed for the in vivo quantitative estimation of Shigella paradysenteriae type III (Z) antigen in mice, by utilization of the minimum quantity found necessary to induce an agglutinin response (0.002 µg). This method was used to determine the fate of this antigen in a mineral oil emulsion at the site of subcutaneous inoculation in mice.

2. Active Shigella antigen was recovered from the site of inoculation in mice at periods up to 18 and 24 weeks, depending on the original dose of antigen. There was a gradual diminution with time in the amount recovered.

3. The deterioration of antigen at the site of inoculation was paralleled by a fall in the agglutinin titers of the mice receiving the oil vaccine.

Footnotes

^* This study was aided by a grant from the Theresa F. Felsen Memorial Fund.