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Biophysical Studies of Blood Plasma Proteins

VI. Immunological Properties of 1-Globulin from the Plasma of Normal Humans¹

From the Departments of Physiological and Physical Chemistry

Abstract

Marked differences in antibody-activity are found in human ₁-and ₂-globulin antibody preparations. The hemagglutinins and typhoid "O" agglutinin appear to be ₁-globulins. The -hemagglutinin of plasma represents a small amount of the high molecular weight portion of the ₁-globulin. The antibody responses of rabbits to human ₁- and ₂-globulins, fibrinogen and albumin as studied by the antigen-dilution technic showed that these essentially electrophoretically pure proteins did not represent distinct immunological entities.

Footnotes

¹ This work has been carried out under a contract, recommended by the Committee on Medical Research, between the Office of Scientific Research and Development and the University of Wisconsin.