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The Appearance of Sheep Cell Lysins and Human a Cell Agglutinins in a Rabbit Immunized with a Partially Purified Blood Group A-Specific Substance from Hog Gastric Mucin

Contribution from The Gates And Crellin Laboratories of Chemistry, California Institute of Technology No. 1089

Abstract

The antigenic power in rabbits of a partially purified A-substance from hog gastric mucin has been observed in one instance. No added protein component was present in the antigen used. This observation suggests that some of the substances present with the A-specific amino acid-polysaccharide complex in mucin confer antigenic properties upon it, just as the conjugated protein component of the somatic antigen of Bact. dysenteriae (Shiga) has been observed to do.

The presence in the partially purified A-substance from hog gastric mucin of one or more substances which are antigenically similar to the Forssman antigen of sheep erythrocytes is indicated by the production of sheep cell lysins when rabbits are immunized with the A-substance. This observation establishes another point of similarity of the A-substances derived from hog mucin and from some human ovarian cyst fluids, of the human agglutinogen A, and of some component of sheep erythrocytes.