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Studies of Antipneumococcal Serum

VI. Changes in Complement-Fixing Activity of Rabbit Sera During Periods of Immunization, Rest, and Reimmunization

From the Division of Laboratories and Research, New York State Department of Health, Albany

Abstract

These studies of type-1 antipneumococcal rabbit sera collected during periods of immunization and rest showed that there was a roughly corresponding quantitative change in complement-fixing capacity and combining activity with type-1 carbohydrate antigen.

In general, during the period of immunization, the complement-fixation titer rose progressively to a maximum as judged both by the amount of complement fixed and by the quantity of antigen needed for maximum fixation by given amounts of serum; it fell rapidly after injections were discontinued but rose again abruptly to a maximum on resumption of immunization, in some instances beyond the earlier maximum.

Irrespective of whether the titer was very low or very high, linear relationships were observed between serum and complement and between serum and antigen. Throughout, the ratio of antigen to serum giving maximum fixation closely approximated "equivalence" proportions.