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Studies on Antireticular Cytotoxic Serum¹

III. Effect of ACS on the Healing of Experimentally Produced Fractures in Rabbits

From the Department of Pathology and Research of the Cedars of Lebanon Hospital, Los Angeles 27, California

Abstract

Following the technic described by the Soviet investigators, with but slight modifications, the effect of ACS on the healing of experimentally produced fractures in rabbits was studied.

The animals were separated into four groups, one being given "stimulating" doses of ACS, another "depressing" doses of ACS, a third give normal goat serum equivalent in volume to the "stimulating" dose of ACS and a fourth given normal goat serum in a volume equivalent to the "depressing" dose of ACS.

The extent of healing of the fractures was evaluated roentgenographically, by gross and microscopic examination of the tissue and by measuring the breaking strength of the line of union.

The results revealed striking differences between the "stimulated" and "depressed" groups of animals and their respective controls. The differences between the average values in each group were subjected to statistical analysis. Probability values for the roentgenographic evaluation failed to reveal significant differences except between the "stimulated" and "depressed" groups of animals on the tenth and fourteenth days of healing and between the "depressed" group of animals and their controls. Statistical evaluation of the breaking strength of the healed fractures, however, indicated highly significant differences between each of the groups and its control.

The experiment was repeated on two additional occasions with similar results.

Stimulation of the healing of experimentally produced fractures in rabbits was induced with small ("stimulating") doses of antireticular cytotoxic serum and depression of healing was produced with large ("depressing") doses as claimed by the Soviet investigators.

Footnotes

¹ These studies were supported by funds established by Mr. Harry Warner, Mr. Harry F. Leveson, Mr. Sidney S. Kingsley, Miss Madge H. Evans, an anonymous donor, and many other donors.