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Studies on Antireticular Cytotoxic Serum

I. Introduction and Review of the Literature

From the Department of Pathology and Research of the Cedars of Lebanon Hospital, Los Angeles 27, California

Abstract

Interest in the Antireticular Cytotoxic Serum of the Soviet investigators was awakened in this country by the report which appeared in the American Review of Soviet Medicine of December, 1943 (1). Because of the claims for its usefulness in the treatment of many disease processes and its inherent promise for longevity, it was deemed advisable to investigate the subject. Articles on the production and experimental and clinical use of Antireticular Cytotoxic Serum abound in the Soviet medical literature and extend back as far as 1924 (2, 3, 4) but they were shrouded by inattention and the language barriers, though one report was made at the Third International Cancer Congress held at Atlantic City in September, 1939 (5).

In 1900 Metchnikoff (6), applying the pharmacological principle that small doses of toxic drugs may stimulate rather than damage, expressed the idea that stimulation of a tissue could be similarly accomplished by the employment of small doses of anti-serum specific for the tissue.