HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Birkhaug, K. Articles by Böe, Johs. Search for Related Content PubMed Articles by Birkhaug, K. Articles by Böe, Johs.

Intradermal Spread of Vital Dye in Anaphylaxis and Bacterial Allergy

From the Medical Department at the Chr. Michelsen Institute, Bergen, Norway (Chief: Konrad Birkhaug, M.Sc., M.D.)

Abstract

The ability of sensitized tissue to retain or fix a specific antigen locally, is a well known phenomenon. Thus Opie (1) has shown that rabbits sensitized with crystalline egg albumin or horse serum, localize these antigens at the point of injection in the skin, without the antigen entering the circulation. Kahn (2) has likewise shown that rabbits sensitized with diphtheria (horse) antitoxin, retain the antigen locally long before any manifestation of anaphylaxis can be demonstrated.

Animals rendered allergic with bacteria possess the same ability to retain the antigen locally. The best example of this fact is offered in experimental tuberculosis. Thus Krause and Willis (3) have shown that if excised lymph-nodes draining the site of inoculation with tubercle bacilli in the normal animal are injected into other normal guinea pigs, it can be demonstrated that the tubercle bacilli reach these lymph-nodes within twenty-four hours.