HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Penn, H. S. Articles by Jacobsen, E. M. Search for Related Content PubMed Articles by Penn, H. S. Articles by Jacobsen, E. M.

A Heterologous Principle in Human Cancerous Liver: Its Effect Upon the Brown-Pearce Tumor^*

From the Department of Zoölogy, University of California, Los Angeles

Abstract

A method for obtaining a heterologous acetone-soluble fraction from human cancerous tissue is described.

This fraction coupled with a protein was employed to obtain an antiserum by injection into rabbits.

Both the acetone-soluble fraction and its antiserum were subjected to experimental procedure by injection into rabbits previously inoculated intraocularly with Brown-Pearce carcinoma.

Two types of controls, both with intraocular implants, were used: (1) noninjected animals and (2) animals injected with normal antigen obtained from human non-cancerous tissue and with normal rabbit serum.

The tumor growth was not modified by injection with normal rabbit serum and acetone-soluble, protein-coupled fraction obtained from human non-cancerous tissue.

Inhibition of tumor growth was demonstrable in those animals inoculated with a rapidly growing Brown-Pearce tumor and injected with a heterologous acetone-soluble lipoid fraction obtained from human cancerous tissue and with its antiserum.

Footnotes

^* These investigations were supported by a grant from the Jewish Fund for Medical Research to the University of California and carried out under the supervision of the Committee on Cancer Research.