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Studies on the Chemotherapy of Viruses in the Psittacosis-Lymphogranuloma Group^*

I. Effect of Penicillin and Sulfadiazine on Ten Strains in Chick Embryos

Abstract

1. The effectiveness of penicillin and sodium sulfadiazine against viruses in the psittacosis-lymphogranuloma venereum group has been tested in chick embryos.

2. Penicillin delayed the death of embryos infected with each of the ten viruses tested.

3. Sodium sulfadiazine had a similar effect only against two classical strains of psittacosis virus, the mouse pneumonitis virus (Greb strain), 12 XN strain, and lymphogranuloma venereum virus, and failed to delay death of embryos infected with Borg strain, SF strain, pigeon or ithosis virus (P 207 strain), meningopneumonitis virus (Cal 10 strain), and feline pneumonitis virus.

Footnotes

^* Studies conducted at Camp Detrick, Frederick, Maryland, from July to September 1945.

¹ Lt., MC, USNR.

² 1st Lt., SnC, AUS.

³ 1st Lt., MAC, AUS.