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The Journal of Immunology, 1946, 53: 371-379.
Copyright © 1946 by The American Association of Immunologists, Inc.

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Chemotherapy of Experimental Anthrax Infections

Edward S. Miller1, Earl B. Scott2, Herbert A. Noe2, Stewart H. Madin3 and Thomas F. Henley4

Studies conducted at Camp Detrick, Frederick, Maryland from 1 February 1945 to 1 August 1945

Abstract

1. Streptomycin, penicillin and sodium sulfadiazine were tested for efficacy in experimental anthrax infections in mice.
2. Maximal survival rates of 92 per cent were obtained with streptomycin, 58 per cent with penicillin, and only 5 per cent with sulfadiazine.
3. Latent infections were not present in treated animals surviving 28 days after inoculation with lethal doses of B. anthracis spores.

Footnotes

1 Captain, MC, A.U.S.

2 Lieutenant, CWS, A.U.S.

3 Ensign, H(S), U.S.N.R.

4 Lieutenant (jg), MC, U.S.N.R.







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