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The Efficiency of Different Sharples Centrifuge Bowls in the Concentration of Tobacco Mosaic and Influenza Viruses¹

From the Department of Animal and Plant Pathology of The Rockefeller Institute for Medical Research, Princeton, New Jersey

Abstract

A study was made of the efficiency of Sharples centrifuge bowls carrying liquid layers 0.5, 0.25 and 0.125 inches thick in the concentration of tobacco mosaic and influenza viruses at different rates of flow. No significant differences in efficiency were found hence it can be concluded that the regular Sharples Laboratory Super Centrifuge equipment is satisfactory for the large scale production of purified and concentrated influenza virus for use in influenza vaccines. A discussion is presented of the distinct advantages which the centrifuge method possesses over all other methods yet reported for the large scale production of concentrated and purified influenza virus for use in vaccines.

Footnotes

¹ The work described in this paper was done in part under a contract, recommended by the Committee on Medical Research, between the Office of Scientific Research and Development and The Rockefeller Institute for Medical Research, and in part with aid through the Commission on Influenza, Board for the Investigation and Control of Influenza and Other Epidemic Diseases in the Army, Preventive Medicine Service, Office of the Surgeon General, United States Army.

² Consultant to Secretary of War and Member, Commission on Influenza, Board for the Investigation and Control of Influenza and Other Epidemic Diseases in the Army, Preventive Medicine Service, Office of the Surgeon General, United States Army.