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Infection of Rats with the Virus of Influenza¹

From the Department of Internal Medicine, Washington University School of Medicine, and the Oscar Johnson Institute for Medical Research, Saint Louis, Missouri

Abstract

Intrabronchial inoculation of rats with heavy suspensions of pulmonary tissues of mice infected with influenza virus produced macroscopic lesions localized to the site of inoculation. When the suspensions were mixed with antiviral serum, the lesion was specifically inhibited. Multiplication of virus in the lungs of rats was indicated by the survival of influenza virus through eleven serial passages The microscopic lesions were noteworthy for the absence of significant changes in the bronchiolar epithelium.

Footnotes

¹ This investigation was aided in part by the Commission on Influenza, Board for the Investigation and Control of Influenza and Other Epidemic Diseases in the Army, Preventive Medicine Service, Office of the Surgeon General, United States Army, and in part by a grant from the Commonwealth Fund.

² Recipient of a research fellowship awarded by Lederle Laboratories, Inc.