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The Antigenic Properties of Fibrin Films and Foams Prepared from Human and from Bovine Blood Plasma¹

From the Armour Laboratories and the Chemical Research Department, Armour and Company, Chicago

Abstract

1. Fibrin film and foam, both human and bovine, prepared by low temperature plasma fractionation methods are strongly antigenic for rabbits before heat sterilization.

2. Such films and foams are non-antigenic after heat sterilization when implanted in rabbits as membranes or hemostatics for surgical purposes.

3. Under special conditions designed to favor antibody production weak antibody response may be obtained from heated films and foams, but such antibodies do not react with heated antigens; the reaction is shown only by unheated antigens or by native proteins from which the antigens were derived.

4. The demonstration that heated films and foams may be weakly antigenic under conditions far removed from surgical use is not regarded as a valid argument against the use, in human surgery, of fibrin film and foam made from a foreign species of plasma.

Footnotes

¹ This work has been carried out, in part, under contract, recommended by the Committee on Medical Research, between the Office of Scientific Research and Development and The Armour Laboratories Division of Armour and Company. Human blood used in this work was collected from donors enrolled by the American Red Cross.

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