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Shigella Sp. Wakefield and its Relations to Shigella Sp. Sachs Q454

Lederle Laboratories, Inc., Pearl River, N. Y.

Abstract

1. The mannitol fermenting Shigellae from the outbreak in Wakefield described by Berger are culturally and serologically different from previously known members of that genus. Two strains are serologically identical. They possess a heat labile and a heat stabile antigen. The third has the same heat labile antigen but differs in its heat stabile antigen. It is therefore suggested to designate these bacteria as Sh. sp. Wakefield A and Sh. sp. Wakefield B respectively.

2. Type Q454 of Sachs possesses

a. a characteristic heat-stabile somatic antigen

b. a heat-labile antigen which is entirely or in a major part similar to that of the Wakefield bacillus. It can only be indirectly demonstrated, namely, by the cross reaction of anti-Q454 serum with Wakefield bacilli, because

c. Q454 has a factor that inhibits agglutination of live bacteria, and for which evidence of antigenicity has not been obtained in the course of the present investigation.

3. The heat labile antigens of Shigella sp. Wakefield and Sachs Q454 are representative for similar antigens in other Enterobacteriaceae. The problems raised by the disclosure of these heat-labile antigens are briefly discussed.