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Studies in Human Malaria¹

IV. An Attempt at Vaccination of Volunteers Against Mosquito-Borne Infection with Pl. Vivax

From the Department of Medicine and the Division of War Research, Columbia University, College of Physicians and Surgeons, and the Presbyterian Hospital, in the City of New York

Alf S. Alving, Branch Craige, Jr.², Ralph Jones, Jr.², Theodore N. Pullman² and Merrill Whorton²

From the Malaria Research Unit, Department of Medicine, University of Chicago, Chicago, Illinois

Abstract

(1) Formalinized malaria vaccine, administered to man in relatively large quantity by various parenteral routes apparently was without serious toxicity. Local inflammatory reactions, chills and fever subsided with repeated administration.

(2) The administration of such vaccine in a dosage of 10 billion formalinized parasites per man over a period of 13–14 days had no effect on susceptibility to infection with malaria by the bite of vivax-infected mosquitoes.

Footnotes

¹ The work described in this paper was carried out under contracts recommended by the Committee on Medical Research, between the Office of Scientific Research and Development, Columbia University, and the University of Chicago. The work was also carried out in part under the Harkness Research Fund of the Presbyterian Hospital in New York City.

² Captain, M.C., AUS.