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The Journal of Immunology, 1946, 52: 231-234.
Copyright © 1946 by The American Association of Immunologists, Inc.

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The Duration of Antibody-Formation after Injection of Killed Typhoid Bacilli in Water-in-Oil Emulsion1

Jules Freund and Mary V. Bonanto

From the Public Health Research Institute of the City of New York, Inc. and the Bureau of Laboratories, Department of Health of the City of New York

Abstract

Agglutinins against typhoid bacilli were found in the sera of one group of rabbits after 3 years and 1 month following 2 simultaneous subcutaneous injections and in another group of rabbits, 3 years and 5 months after the second subcutaneous injection of killed typhoid bacilli suspended in salt solution and incorporated into a mixture of a lanolin-like substance and oil.

Footnotes

1 This study was aided by a grant from the John and Mary R. Markle Foundation.







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