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The Effects of Immunization with Histamine Azoprotein on Histamine-Intoxication and Passive Anaphylaxis in the Guinea-Pig¹

From the Departments of Neurology and Bacteriology, College of Physicians and Surgeons, Columbia University and the Neurological Institute, New York

Abstract

1. Treatment of guinea-pigs by a series of subcutaneous injections of histamine azoprotein, as an alum precipitate or with adjuvants, confers little or no protection against the effects of one MLD histamine injected intravenously.

2. Guinea-pigs can be protected against passive anaphylaxis by a series of subcutaneous injections of histamine azoprotein. The protective effect is enhanced by adjuvants.

3. Immunization with human serum and adjuvants appears to protect guinea-pigs against passive anaphylaxis to approximately the same degree as treatment with histamine azoprotein and adjuvants, although adjuvants alone confer little or no protection against passive anaphylaxis.

4. One or two subcutaneous injections of histamine azoprotein can sensitize a guinea-pig so that fatal anaphylaxis results after an intravenous injection of histamine azoprotein.

Footnotes

¹ Aided in part by grants from the William J. Matheson Commission.