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Studies on Bacterial Viruses

I. The Effect of Certain Compounds on the Lysis of Escherichia Coli by Bacteriophage

Stamford Research Laboratories, American Cyanamid Company, Stamford, Connecticut

Abstract

1. A method has been described by which compounds may conveniently be tested for inhibition of lysis of bacteriophage infected organisms.

2. Of the compounds tested by this method the acridines as a group were most effective.

3. Tests run with one such acridine compound, Phosphine GRN, suggest that its activity may be due to interference with some process necessary to virus multiplication in the infected cell.

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