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The Use of Papaverine Hydrochloride in the Prevention of Anaphylactic Shock in Guinea Pigs

Abstract

1. It has been shown that papaverine hydrochloride in varying dosages used as pretreatment failed to prevent fatal histamine shock, whereas it did prevent fatal anaphylactic shock in 53 per cent of the guinea pigs used.

2. This seemingly different activity on the part of papaverine in histamine shock and anaphylactic shock, it is suggested, is not due to a selective success against the unknown of anaphylaxis and failure against histamine, but rather to the probable difference of concentrations of histamine at the site of the shock organs in the two different types of shock, under the circumstances of the experiment.

3. A review of several of the means of obtaining an anti-histamine effect is discussed, and the failure of papaverine to prevent all the effects generally attributable to histamine in shock, leads us to class it as not a very effective bronchial dilator.