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Studies with the Somatic Antigen of Shigella Paradysenteriae (Flexner)¹

From the Department of Bacteriology, School of Medicine, University of Pennsylvania

Abstract

1. The somatic antigen which is present in the surface of the bacterial cell of Shigella paradysenteriae is the principal component of the cell concerned in mouse protection and agglutination.

2. The somatic antigen is an extremely potent antigen. In one instance, by active immunization of mice, 50 per cent protection against 100,000 MLD was obtained with as little as 0.077 µg of the antigen.

3. The somatic antigen seems to be the principal carrier of the toxicity of the whole organism.

4. The isolated somatic antigen does not seem to be superior to the killed whole bacterial cell as a prophylactic vaccine against bacillary dysentery.

Footnotes

¹ The work described in this paper was done under a contract, recommended by the Committee on Medical Research, between the Office of Scientific Research and Development and the University of Pennsylvania.