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The Determination of Meningococcic Antibodies by a Centrifuge-Agglutination Test¹

From the George Washington Medical Division, Gallinger Muncipal Hospital, and the Department of Medicine, George Washington University

Abstract

1. A method for the determination of agglutinins against N. intracellularis by the use of the centrifuge is described and the theoretical reasons for its superiority are given.

2. Four hundred and four specimens of serum from 121 subjects with and without meningococcal infections were examined by this method.

3. The maximum agglutinin titer in the majority of the patients with meningococcic infections, or receiving antimeningococcic serum, was 1:16 or more, and titers ran up as high as 1:1024. Among the 35 control patients the maximum titer was above 1:8 in only two instances.

4. It is concluded that the centrifuge-agglutination test is simple to perform and achieves a high degree of specificity combined with sufficient sensitivity for all practical uses.

Footnotes

¹ Aided by a grant from the Lederle Laboratories, Inc.