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Immunologic Studies in Rheumatic Fever

I. Cutaneous Response to Type-Specific Proteins of the Hemolytic Streptococcus

B. Response to "Purified M" Proteins from Forty Known Types of the Hemolytic Streptococcus—Group A

From the St. Francis Sanatorium for Cardiac Children, Roslyn, L. I., New York

Abstract

1. Cutaneous reaction to the "purified M" fraction of each of the 40 known types of the hemolytic streptococcus was investigated in active and quiescent rheumatic children, 6–16 years of age.

2. The incidence of positive cutaneous reactions and the degree of cutaneous reactivity is higher in the group of children having active rheumatic disease. Active rheumatic children react to a larger number of types of the hemolytic streptococcus than the quiescent group.

3. Cutaneous reactivity to the known 40 types of the hemolytic streptococcus in rheumatic children increases significantly with the age of the child.

4. The incidence, degree, and universality of cutaneous reactivity to the family of known hemolytic streptococci in Group A, decrease with lapse of time from the acute rheumatic episode for about 2 years; after this period cutaneous reactivity increases with the age of the child.

5. The incidence and degree of cutaneous reaction in rheumatic patients to the "purified M" fraction of certain types of hemolytic streptococci are significantly greater than of others.