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Studies on the Hemolytic Streptococcus

VII. Comparison of the Results of Immunization Against Scarlet Fever with Toxin and Aluminum-Adsorbed Toxoid of Streptococcus Scarlatina (NY5)¹

From the Department of Pathology, University of Pittsburgh and Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania

Abstract

1. Comparison of toxoid and toxin as an antigen in immunization against scarlet fever warrants the conclusion that the former gives equally good, if not better, results with less local and systemic reactions. This is especially true in younger children.

2. Because of variable degree of refractoriness to immunizing injections among positive reactors it is recommended that readily immunizable individuals be eliminated following three comparatively small doses of antigen by a Dick retest and that further immunization procedures be continued with the remaining positive reactors of the more refractory group.

Footnotes

¹ This study was aided in part by a gift from Mrs. George M. Laughlin, III.

² Present address, University Hospital, University of Maryland, Baltimore.